Peer-reviewed veterinary case report
Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.
- Journal:
- Advanced materials (Deerfield Beach, Fla.)
- Year:
- 2016
- Authors:
- Kang, Jinyoung et al.
- Affiliation:
- Department of Nanoengineering · United States
Abstract
Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27383373/