Peer-reviewed veterinary case report
Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation.
- Journal:
- Cell stem cell
- Year:
- 2018
- Authors:
- Kokaia, Zaal & Lindvall, Olle
- Affiliation:
- Lund University Hospital
Abstract
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory prostaglandin E2 and scavenging succinate. This mechanism reduces CNS damage and ameliorates motor impairment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29499143/