Peer-reviewed veterinary case report
SEPPIC vaccine adjuvants for poultry.
- Journal:
- Annals of the New York Academy of Sciences
- Year:
- 2006
- Authors:
- Dupuis, L et al.
- Affiliation:
- SEPPIC · France
Abstract
Two inactivated antigens (Newcastle and Pasteurella Multocida) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide ISA 70 for W/O formulations and Montanide ISA 206 for W/O/W when safety is the priority.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17135512/