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Peer-reviewed veterinary case report

Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.

Journal:
Antimicrobial agents and chemotherapy
Year:
2006
Authors:
Kirkpatrick, William R et al.
Affiliation:
The University of Texas Health Science Center at San Antonio · United States
Species:
rodent

Abstract

We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/16569887/