Peer-reviewed veterinary case report
Thyroid hormone changes in dogs hospitalized with parvovirus
By Oikonomidis, I L et al.·Published in Veterinary journal (London, England : 1997)·2021·The Royal (Dick) School of Veterinary Studies and The Roslin Institute, United Kingdom·View original on PubMed →
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Original publication title: Serial measurement of thyroid hormones in hospitalised dogs with canine parvoviral enteritis: Incidence of non-thyroidal illness syndrome and its association with outcome and systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of 28 dogs with canine parvoviral enteritis (CPVE) were hospitalized for at least five days, and many showed low levels of thyroid hormones during their stay. This condition, known as non-thyroidal illness syndrome, was common and linked to a worse outcome, especially in dogs that developed systemic inflammatory response syndrome (SIRS). By the fifth day, the dogs that survived had higher thyroid hormone levels compared to those that did not make it. Monitoring these hormone levels could help predict which dogs are more likely to recover from CPVE.
People also search for: dog parvovirus treatment · low thyroid hormones in dogs · canine parvoviral enteritis symptoms
Abstract
The aim of this study was to serially evaluate the serum concentrations of total thyroxine (tT4), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) in dogs with canine parvoviral enteritis (CPVE) during a 5-day hospitalisation period and assess the association of these hormone concentrations with the outcome and the development of systemic inflammatory response syndrome (SIRS). Dogs with confirmed CPVE that were hospitalised for at least 5 days were included. The thyroid hormones concentrations were measured on days 1, 3 and 5 of hospitalisation. Twenty-eight dogs were included. All (28/28, 100%), 19/28 (69.7%) and 23/28 (82.1%) dogs had a low serum tT4, fT4 and TSH concentration, respectively, on at least 1 day during the hospitalisation period. Overall, 11/28 (39.3%) dogs were diagnosed with SIRS on at least 1 day. In survivors, serum tT4 concentration was significantly higher on day 5 (median, range: 11.8 nmol/L, <6.4-32.2 nmol/L) compared to those on days 1 (<6.4 nmol/L, <6.4-20.1 nmol/L; P = 0.010) or 3 (7.6 nmol/L, <6.4-25.2 nmol/L; P = 0.019). Survivors had a significantly higher tT4 concentration (median, range: 11.8 nmol/L, <6.4-32.2 nmol/L) on day 5 compared to non-survivors (<6.4 nmol/L, <6.4-7.2 nmol/L; P = 0.002). Regardless of the day of hospitalisation, dogs with SIRS had significantly lower tT4 (<6.4 nmol/L, <6.4-16.3 nmol/L) compared to dogs without SIRS (8.6 nmol/L, <6.4-32.2 nmol/L; P = 0.006). A significant difference was also found in fT4 between dogs with SIRS (<3.9 pmol/L, <3.9-16.2 pmol/L) and dogs without SIRS (15.1 pmol/L, <3.9-59.2; pmol/L; P < 0.001). Non-thyroidal illness syndrome was frequently observed in dogs with CPVE, and a negative association between tT4 and fT4 concentrations and SIRS was noted. Serial measurements of tT4 concentrations appeared to have prognostic value.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34252549/