Peer-reviewed veterinary case report
Serial passage of sheep scrapie inoculum in Suffolk sheep.
- Journal:
- Veterinary pathology
- Year:
- 2009
- Authors:
- Hamir, A N et al.
- Affiliation:
- National Animal Disease Center · United States
Abstract
Scrapie is a naturally occurring fatal neurodegenerative disease of sheep and goats. Susceptibility to the disease is partly dependent upon the genetic makeup of the host. In a recent study, it was shown that sheep intracerebrally inoculated with a US scrapie agent (No. 13-7) developed scrapie and survived for an average of 19 months post inoculation. In the present study, when this scrapie inoculum was further passaged for 3 successive generations, the survival time was reduced by approximately 8 months in scrapie-susceptible (QQ on prion protein gene [PRNP] at codon 171) Suffolk sheep. It is concluded that inoculum No. 13-7 appears to have been stabilized in susceptible (171 QQ) Suffolk sheep and may be considered a specific isolate of sheep scrapie agent in the USA and therefore that it can be used to evaluate other isolates of sheep scrapie in this country.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19112113/