Peer-reviewed veterinary case report
Blood and stool tests to predict treatment response in dogs
By Otoni, Cristiane C et al.·Published in Journal of veterinary internal medicine·2018·Internal Medicine Department, United States·View original on PubMed →
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Original publication title: Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of 16 dogs with idiopathic inflammatory bowel disease (IBD) showed signs of gastrointestinal issues, such as vomiting and diarrhea. Researchers measured certain markers in their blood and stool before and after 21 days of treatment. After treatment, the levels of inflammation markers in both blood and stool significantly decreased, indicating that the dogs were responding well to the therapy. This study suggests that checking stool markers can help vets assess the severity of IBD and monitor treatment effectiveness.
People also search for: dog IBD treatment · dog vomiting diarrhea · inflammatory bowel disease in dogs · stool test for dog inflammation · dog gastrointestinal issues treatment
Abstract
BACKGROUND: Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD). OBJECTIVES: Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment. ANIMALS: Sixteen dogs with idioptahic IBD and 13 healthy dogs. METHODS: Prospective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment. RESULTS: Serum CRP (median 3.5 mg/L; range: 0.1-52.4 mg/L), fecal cCP (median 92.3 μg/g; range: 0.03-637.5 μg/g), and CIBDAI scores significantly increased in dogs with IBD before treatment compared with serum CRP (median 0.2 mg/L; range: 0.1-11.8 mg/L; P < .001), fecal cCP (median 0.67 μg/g; range: 0.03-27.9 μg/g; P < .001) and CIBDAI (P < .001) after treatment. No significant associations between CIBDAI scores and before or after treatment serum biomarkers. There was a significant association between fecal cCP and CIBDAI scores before treatment (rho = 0.60, P = .01). CRP and fecal cCP significantly decreased after treatment (median 3.5 mg/L v. 0.2 mg/L; P < .001 and 92.3 μg/g v. 0.67 μg/g; P = .001, respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: Our data indicate that measurement of fecal cCP concentration is a useful biomarker for noninvasive evaluation of intestinal inflammation. Dogs with severe signs of GI disease more often have abnormal markers than dogs having less severe disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29624721/