Peer-reviewed veterinary case report
Rabies antibody levels in dogs in Mumbai tested by ELISA
By Nale, J M et al.·Published in Comparative immunology, microbiology and infectious diseases·2021·Department of Microbiology, India·View original on PubMed →
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Original publication title: Serosurveillance of rabies antibodies in dogs in Mumbai region by using indirect ELISA.
- Species:
- dog
Plain-English summary
In a study of dogs in the Mumbai region, researchers found that about 39% of the dogs tested had protective levels of antibodies against rabies after receiving the vaccine. Specifically, 86.66% of pet dogs had sufficient antibodies, indicating they were protected. However, many stray dogs showed low levels of these antibodies, which puts them at risk for rabies and could pose a threat to other animals and people. This highlights the importance of vaccinating all dogs to prevent the spread of this deadly virus.
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Abstract
Rabies is a highly fatal viral infection of the central nervous system affecting all warm-blooded animals including humans. To implement the preventive and control measures, it is important to decide the status of anti-rabies antibodies in dogs. Out of 120 serum samples, 47 (39.2 %) serum samples, showed an antibody titre equal to or above the cut off value of 0.5 IU/ml. The maximum number of dogs showed anti-rabies antibody titres equal to or above the cut-off value of 0.5 IU/ml after <1 month pre-exposure to the rabies vaccine. In 15 serum samples of pet dogs, we observed 13 (86.66 %) dogs with protective anti-rabies antibody titre. Statistical analysis suggests that the age of the animal had no significant effect on anti-rabies antibody titre in vaccinated pet dogs. The overall low seroprevalence of anti-rabies antibody in stray dogs indicates their susceptibility to rabies infection and thus posing a risk of rabies to other animals and humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33930629/