Peer-reviewed veterinary case report
Serotonergic and dopaminergic systems are implicated in antidepressant-like effects of chotosan, a Kampo formula, in mice.
- Journal:
- Journal of pharmacological sciences
- Year:
- 2017
- Authors:
- Sasaki-Hamada, Sachie et al.
- Affiliation:
- Faculty of Pharmaceutical Sciences · Japan
- Species:
- rodent
Abstract
We previously demonstrated that chotosan (CTS), a traditional herbal formula called Kampo medicine, improves diabetes-induced cognitive deficits. In the present study, we investigated the antidepressant-like effects of CTS in mice. The administration of CTS (1.0 g/kg, for 3 days) decreased the immobility time in the forced-swim test, and this decrease was prevented by the prior administration of sulpiride (an antagonist of Dreceptors) and WAY100635 (an antagonist of 5-HTreceptors). None of the treatments tested altered the locomotor activity of mice. These results suggest that CTS exerts antidepressant-like effects through changes in the serotonergic and dopaminergic systems.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28233634/