Peer-reviewed veterinary case report
Vitamin D, CRP, and von Willebrand levels in dogs with chronic liver
By Ambrosini, Yoko M et al.Ā·Published in Journal of veterinary internal medicineĀ·2022Ā·Washington State University, United StatesĀ·View original on PubMed ā
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Original publication title: Serum 25-hydroxyvitamin D and C-reactive protein and plasma von Willebrand concentrations in 23 dogs with chronic hepatopathies.
- Species:
- dog
Plain-English summary
A group of 23 dogs with chronic liver disease (hepatopathy) had blood tests to measure vitamin D, C-reactive protein (CRP), and von Willebrand factor (vWF) levels. The results showed that lower vitamin D levels were linked to more severe liver damage, while higher CRP and vWF levels indicated worse disease conditions. These findings suggest that measuring these substances in the blood could help veterinarians assess the severity of liver disease in dogs without needing a liver biopsy. This could lead to better monitoring and treatment decisions for affected pets.
People also search for: dog liver disease symptoms Ā· vitamin D levels in dogs Ā· chronic hepatopathy treatment in dogs
Abstract
BACKGROUND: Serum concentrations of 25-hydroxyvitamin D (25(OH)VD) and C-reactive protein (CRP) and von Willebrand's factor (vWF) concentration correlate with histopathologic disease grade and stage in chronic inflammatory and fibrotic hepatopathies (CH) in humans. OBJECTIVES: To evaluate serum 25(OH)VD and serum CRP concentrations and plasma vWF concentration and determine if they correlate with histopathologic and biochemical variables in dog with CH. ANIMALS: Twenty-three client-owned dogs with a histopathologic diagnosis of CH were prospectively enrolled. METHODS: Blood samples were collected before liver biopsy. Correlations between biomarkers and clinical pathological and histopathologic variables were evaluated using Pearson's or Spearman's test. RESULTS: Serum 25(OH)VD concentration (median, 213 nmol/L; range, 42-527 nmol/L) was negatively correlated with serum aspartate aminotransferase activity (AST; rho = -0.59, P < .01), polymorphonuclear neutrophil count (PMN; r = -0.46, P < .05), and positively correlated with serum albumin concentration (r = 0.69, P < .001). Serum CRP concentration (median, 7.4 μg/L; range, 1-44.9 μg/L) was positively correlated with overall histopathologic necroinflammatory activity (r = 0.78, P < .001) and fibrosis score (rho = 0.49, P < .05). Plasma vWF concentration (median, 73.3%; range, 15-141%) was positively correlated with fibrosis score (r = 0.53, P < .05) and prothrombin time (rho = 0.67, P < .01), and negatively correlated with serum albumin concentration (r = -0.73, P < .001). CONCLUSION AND CLINICAL IMPORTANCE: In dogs with CH, serum 25(OH)VD concentration was negatively correlated with disease activity, whereas serum CRP concentration and plasma vWF concentration were positively correlated with histopathologic grade and stage. Our results provide preliminary evidence that these biomarkers may be useful to assess grade and stage of CH in dogs in the absence of liver biopsy.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35420222/