Peer-reviewed veterinary case report
Adipokine levels in dogs with acute pancreatitis compared to healthy
By Paek, J et al.·Published in Journal of veterinary internal medicine·2014·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Serum adipokine concentrations in dogs with acute pancreatitis.
- Species:
- dog
Plain-English summary
A 5-year-old Labrador was diagnosed with acute pancreatitis after showing symptoms like vomiting and abdominal pain. Researchers compared blood samples from this dog and others with pancreatitis to healthy dogs, finding that certain substances in the blood were higher in dogs with pancreatitis. After treatment, some of these substances decreased, indicating that they might be linked to the dog's recovery. The study suggests that monitoring these blood markers could help understand and manage pancreatitis in dogs better.
People also search for: dog pancreatitis symptoms · Labrador vomiting treatment · dog blood test results pancreatitis
Abstract
BACKGROUND: Limited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs. OBJECTIVES: To determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors. ANIMALS: Twenty-eight healthy dogs and 25 client-owned dogs with AP. METHODS: Prospective observational cohort study of 25 client-owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)-α were measured. RESULTS: The serum concentrations of leptin (P = .0021), resistin (P = .0010), visfatin (P < .0001), IL-1β (P < .0001), IL-6 (P = .0002), IL-10 (P < .0001), and IL-18 (P < .0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P = .0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P = .028) and adiponectin (P = .046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P = .037) and IL-1β (P = .027) decreased significantly, whereas the serum concentrations of leptin (P > .999), adiponectin (P = .11), visfatin (P = .83), IL-6 (P = .82), IL-10 (P = .82), IL-18 (P = .56), and TNF-α (P = .94) did not differ significantly. CONCLUSION AND CLINICAL IMPORTANCE: This study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25312217/