Peer-reviewed veterinary case report
Blood levels of amikacin in dogs treated with topical wound gel
By Peng, Zong H et al.·Published in Veterinary surgery : VS·2025·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Serum amikacin concentrations in dogs with naturally occurring open wounds treated with topical amikacin in carboxymethylcellulose hydrogel.
- Species:
- dog
Plain-English summary
Eleven dogs with open wounds were treated with a topical gel containing amikacin, an antibiotic, to help manage their infections. Blood samples were taken before and after applying the gel to check for any absorption into the bloodstream. Results showed that only a few samples had detectable levels of amikacin, indicating that the gel is likely safe and effective without causing high levels of the drug in the blood. This treatment could be a good option for dogs with tough infections or biofilms on their wounds.
People also search for: dog wound care treatment · amikacin gel for dogs · antibiotic gel for dog wounds
Abstract
OBJECTIVE: To quantify serum amikacin concentrations in dogs undergoing wound management with topical amikacin (45 mg/mL) 3% carboxymethylcellulose hydrogel. STUDY DESIGN: Prospective clinical study. SAMPLE POPULATION: Eleven client-owned dogs. METHODS: Dogs with naturally occurring wounds, undergoing treatment with topical amikacin gel, were enrolled. A whole blood sample was collected prior to initial application of the gel. Up to a maximum dose of 30 mg/kg of gel, was applied directly on the wound and the wound was bandaged. Serial blood sampling was performed at approximately 2, 4, 8, 12, 18, 24, 32, 40, 48, 56, 64, and 72 h after application of amikacin gel. The sampling schedule was reset following each bandage change and new application of the gel. Up to 20 samples per dog were collected. The Siemens Syva EMIT Amikacin Assay was used to quantify the concentration of amikacin in each blood serum sample. The lower limit of quantification (LLOQ) of the test was 2.5 μg/mL. RESULTS: Amikacin gel was applied a total of 31 times (dose range, 0.1-24.9 mg/kg). A total of 153 samples were analyzed. Five samples in three different dogs were above the LLOQ at approximately 2 h after gel application (range 2.75-3.82 μg/mL). All other samples were below the LLOQ. CONCLUSION: Routine use of amikacin gel for open wound management did not result in serum amikacin levels above 5 μg/mL. CLINICAL SIGNIFICANCE: Topical amikacin gel may be a safe treatment option for wounds in dogs with resistant infections or biofilms.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39651702/