Peer-reviewed veterinary case report
Serum amino acid levels in dogs with immunosuppressant-responsive
By Benvenuti, Elena et al.·Published in BMC veterinary research·2020·Department of Veterinary Science, Italy·View original on PubMed →
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Original publication title: Serum amino acid profile in 51 dogs with immunosuppressant-responsive enteropathy (IRE): a pilot study on clinical aspects and outcomes.
- Species:
- dog
Plain-English summary
A group of 51 dogs with immunosuppressant-responsive enteropathy (IRE) showed lower levels of certain amino acids, including tryptophan, compared to 26 healthy dogs. These dogs were assessed for their response to treatment over a month, with some improving while others did not. The study suggests that lower levels of specific amino acids could indicate how well a dog might respond to therapy for this intestinal disease. Further research is needed to confirm these findings and potentially use these amino acids as markers for treatment outcomes.
People also search for: dog inflammatory bowel disease symptoms · dog amino acid levels treatment · immunosuppressant therapy for dogs
Abstract
BACKGROUND: Lower levels of tryptophan (TRP) have been identified in people with inflammatory bowel disease and in dogs with protein-losing enteropathy (PLE). No data on serum amino acids (AAs) but some on plasma in canine immunosuppressant-responsive enteropathy (IRE) are available. The aim of this study is to compare serum AAs between healthy and IRE dogs, considering clinicopathological variables and follow-up. RESULTS: Twenty-six healthy control dogs (CD) and 51 IRE dogs were included. IRE was diagnosed after the exclusion of extra-intestinal diseases and food and antibiotic responsive enteropathies. The canine chronic enteropathy clinical activity index (CCECAI) was assessed at presentation and during the clinical follow-up. In CD and IRE dogs, 19 different serum AAs were measured. IRE dogs were classified into responders, partial responders and non-responders, based on CCECAI after 1 month, and divided into PLE and non-PLE, based on albumin level. IRE dogs showed lower L-Tyrosine (TYR), L-Phenylalanine (PHE) and TRP (p < 0.001) and higher L-Serine (SER), L-Glutamic acid (GLU), L-Arginine (p < 0.001), L-Threonine (p = 0.013), Proline (p = 0.044), L-Cysteine (p = 0.003), L-Valine (p = 0.018), L-Lysine (p = 0.01) and L-Isoleucine (p = 0.005) than CDs. PLE dogs showed lower L-Histidine (HIS) (p = 0.008), PHE (p = 0.005) and TRP (p = 0.005) than non-PLE dogs. In IRE dogs, median GLU was significantly lower in dogs with BCS 3/9 than BCS 5/9 category (p = 0.036). Total protein was positively correlated with PHE and TRP (both p = 0.031, r = 0.30) and albumin was positively correlated with HIS (p = 0.025, r = 0.31), PHE and TRP (both p = 0.001, r = 0.46). HIS (p = 0.041), PHE (p = 0.047) and TRP (p = 0.044) concentrations were significantly lower in non-responders than in responders and partial responders. CONCLUSIONS: This study may suggest further investigation on serum, HIS, PHE, TRP and TYR as markers of intestinal disease and proposed HIS, PHE and TRP as prognostic marker for response to therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32321505/