Peer-reviewed veterinary case report
C-reactive protein levels in dogs with degenerative joint disease
By Boal, S & Miguel Carreira, L·Published in Veterinary research communications·2015·Anjos of Assis Veterinary Medicine Centre (CMVAA)·View original on PubMed →
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Original publication title: Serum and synovial fluid C-reactive protein level variations in dogs with degenerative joint disease and their relationships with physiological parameters.
- Species:
- dog
Plain-English summary
A group of 48 dogs with degenerative joint disease (DJD) were tested for levels of C-reactive protein (CRP), which is a marker for inflammation. The study found that while the dogs had normal serum CRP levels, the levels in their joint fluid were lower. Factors like obesity, pain, and the severity of DJD affected the serum CRP levels, but not the joint fluid levels. This research helps establish a baseline for CRP levels in dogs with DJD, which could assist veterinarians in monitoring inflammation in these patients.
People also search for: dog joint pain inflammation · degenerative joint disease in dogs · C-reactive protein levels in dogs
Abstract
Degenerative joint disease (DJD) is a progressive, chronic joint disease with an inflammatory component promoting an acute phase protein (APP) response. C-reactive protein (CRP) is one of the most important APPs, used as an inflammation marker in human, but not veterinary medicine. The study was developed in a sample of 48 dogs (n = 48) with DJD and aimed to: 1) identify and quantify the synovial fluid CRP (SFCRP) in these specimens using a validated ELISA test for serum CRP (SCRP) detection and quantification; and 2) to study the possible relationship between SCRP and SFCRP levels variations in DJD patients evaluating the influence of some physical parameters such as gender, body weight, pain level, DJD grade, and the physical activity (PA) of the patients. Statistical analysis considered the results significant for p values <0.05. Our study showed that it is possible to detect and quantify SFCRP levels in DJD patients using a previously validated canine SCRP ELISA test, allowing us to point out a preliminary reference value for SFCRP in patients with DJD. Although, individuals with DJD presents SCRP values within the normal reference range and the SFCRP levels were always lower. Obesity, pain, and the DJD grade presented by the patients are conditions which seem to influence the SCRP levels but not the SFCRP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26178643/