Peer-reviewed veterinary case report
Cystatin C levels in blood and urine of cats with FIV
By Ghys, Liesbeth FE et al.·Published in Journal of Feline Medicine and Surgery·2015·Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium·View original on Crossref →
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Original publication title: Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism
- Species:
- cat
Plain-English summary
A group of cats with hyperthyroidism had higher levels of a protein called cystatin C in their blood and urine compared to healthy cats, indicating possible kidney issues. In contrast, cats infected with feline immunodeficiency virus (FIV) did not show increased levels of this protein, but they did have higher serum creatinine levels, which can suggest kidney problems. This suggests that hyperthyroidism may affect kidney function more than FIV. If your cat has hyperthyroidism or FIV, it's important to monitor their kidney health with your veterinarian.
People also search for: cat hyperthyroidism kidney problems · feline immunodeficiency virus symptoms · cystatin C in cats
Abstract
Objectives The objective of this study was to investigate serum cystatin C (sCysC) and urinary cystatin C (uCysC) in cats with hyperthyroidism and cats with feline immunodeficiency virus (FIV). Methods Thirty cats with FIV, 26 hyperthyroid cats and 28 healthy cats were included. sCysC and uCysC:creatinine (uCysC/uCr) ratio were measured with a human particle-enhanced nephelometric immunoassay, previously validated for feline CysC measurement. Routine renal variables (serum creatinine [sCr], urine specific gravity, urinary protein:creatinine ratio [UPC]) were also measured in the three groups. Results Cats with hyperthyroidism had significantly higher sCysC and higher uCysC/uCr ratio, lower sCr and a higher UPC than healthy cats. Cats with FIV infection did not show a significantly higher sCysC concentration but had a significantly higher sCr and UPC than healthy cats. uCysC could be detected in only four of them. Conclusions and relevance This study demonstrated that sCysC is increased in cats with hyperthyroidism, in contrast with sCr, but not in cats with FIV. Many hyperthyroid cats, but only four cats with FIV, had an elevated uCysC/uCr ratio. Further studies may reveal if uCysC might be a valuable marker for tubular dysfunction in cats.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/1098612x15592343