Peer-reviewed veterinary case report
Antimullerian hormone levels in female cats with ovarian issues
By Gozer, Ahmet et al.·Published in Theriogenology·2023·Hatay Mustafa Kemal University·View original on PubMed →
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Original publication title: Serum antimüllerian hormone concentrations in female cats. Relation with ovarian remnant syndrome, ovarian cysts and gonadectomy status.
- Species:
- cat
Plain-English summary
A study looked at 31 female cats to understand how a hormone called antimüllerian hormone (AMH) relates to conditions like ovarian remnant syndrome (where ovarian tissue remains after spaying) and ovarian cysts. The researchers found that intact (not spayed) cats had higher levels of AMH compared to spayed cats, which had very low levels. While AMH levels could help determine if a cat has been spayed, they weren't effective in diagnosing ovarian remnant syndrome or ovarian cysts. This means that if your cat has symptoms related to these conditions, AMH testing might not give you the answers you need, and further evaluation by a vet would be necessary.
People also search for: cat ovarian remnant syndrome symptoms · cat ovarian cyst treatment · spayed cat hormone levels
Abstract
The aim of this study was to reveal (1) the determination of the serum antimüllerian hormone concentrations in cats with ovarian remnant syndrome and ovarian cyst, (2) the effectiveness of the serum antimüllerian hormone concentrations in detecting gonadectomy status, and (3) ovarian expression of the antimüllerian hormone in the ovarian cysts and ovarian remnant tissue. For this purpose, a total of 31 domestic cats older than 1 year, including ORS (n = 9), OC (n = 3), spayed (n = 8), and intact (n = 11), were used in the study. Serum and intrafollicular AMH concentrations were determined by the electrochemiluminescence immunoassay, and expression of the AMH was determined by the immunohistochemical method. The serum AMH concentration in the ORS group was 1.49 ± 1.24 ng/ml (0.10-3.63 ng/ml) whereas it was 1.78 ± 0.92 ng/ml (0.8-2.63 ng/ml) in the OC group. AMH concentration in the intrafollicular fluid was determined as 0.023 ng/ml in a cat with an ovarian cyst. While the serum AMH concentration was below 0.01 ng/ml in spayed cats, it was 5.80 ± 3.30 ng/ml (1.88-11.86 ng/ml) in the intact cats. There was a significant difference between the spayed and intact groups in terms of serum AMH concentration (p < 0.05). Moreover, in cats with ovarian cyst and ovarian remnant syndrome, no difference was found between the groups in terms of serum AMH concentration (p > 0.05). No difference was found between the ovarian remnant syndrome and intact cats in terms of serum AMH concentration (p > 0.05). In immunohistochemical staining, ovarian cysts were found to be negative for AMH while a moderate (+2) AMH positivity was observed in other follicles. Furthermore, in cats with ovarian remnant syndrome, severe (+3) AMH positivity was observed. As a result, it was determined that gonadectomy status can be accurately diagnosed by the AMH measurement. Ovarian remnant syndrome cannot be diagnosed accurately by AMH measurement. In addition, it was found that AMH did not seem to play a role in the pathogenesis of ovarian cysts in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36805247/