Peer-reviewed veterinary case report
Oxidative stress blood markers in dogs with inflammatory bowel disease
By Rubio, C P et al.·Published in Veterinary journal (London, England : 1997)·2017·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Serum biomarkers of oxidative stress in dogs with idiopathic inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) showed signs of oxidative stress, which means their bodies were struggling to fight off damage from harmful molecules. Researchers compared blood samples from 18 dogs with IBD to 20 healthy dogs and found that the sick dogs had lower levels of antioxidants and higher levels of oxidants. This suggests that oxidative stress might contribute to the problems seen in dogs with IBD. While the study didn't focus on treatments, understanding this link could help veterinarians develop better management strategies for dogs suffering from IBD.
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Abstract
The objective of this work was to study and compare a panel of various serum biomarkers evaluating both the antioxidant response and oxidative damage in dogs with idiopathic inflammatory bowel disease (IBD). Eighteen dogs with IBD and 20 healthy dogs were enrolled in the study. Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of the plasma (FRAP), total thiol concentrations, and paraoxonase 1 (PON1) activity were evaluated in serum to determine antioxidant response. To evaluate oxidative status, ferrous oxidation-xylenol orange (FOX), thiobarbituric acid reactive substances (TBARS) and reactive oxygen species production (ROS) concentrations in serum were determined. Mean concentrations of all antioxidant biomarkers analyzed, with exception of FRAP, were significantly lower (P < 0.0001) in the sera of dogs with IBD than in healthy dogs. The oxidant markers studied were significantly higher (P < 0.0001) in sera of dogs with IBD than in healthy dogs. These findings support the hypothesis that oxidative stress could play an important role in the pathogenesis of canine IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28283081/