Peer-reviewed veterinary case report
Changes in dog blood enzymes during endotoxemia and choline treatment
By Tvarijonaviciute, Asta et al.·Published in Research in veterinary science·2012·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Serum butyrylcholinesterase and paraoxonase 1 in a canine model of endotoxemia: effects of choline administration.
- Species:
- dog
Plain-English summary
A group of mongrel dogs experienced inflammation after being injected with a substance that mimics infection. The dogs were divided into groups, with some receiving choline, a nutrient that may help during inflammation. The results showed that the dogs given choline had less decrease in certain liver enzymes related to inflammation compared to those that did not receive it. This suggests that choline may help support liver function during inflammatory conditions.
People also search for: dog inflammation treatment · choline for dogs · liver enzymes in dogs
Abstract
Butyrylcholinesterase (BChE) and paraoxonase 1 (PON1) are two serum enzymes synthesized by the liver that are related with inflammation. The main objectives of this study were to determine changes in serum BChE and PON1 by using a canine model of endotoxemia, and to evaluate whether choline alters BChE and PON1 activities during inflammation. For this purpose, a total of 20 mongrel dogs were divided into four groups: control, choline (C), lipopolysaccharide (LPS), and LPS+C. Dogs in the control group were injected with 0.9% NaCl (0.2 ml/kg, i.v.). Dogs in C and LPS+C groups received choline chloride (20 mg/kg, i.v., three times with 4 h intervals). Endotoxin was injected (0.02 mg/kg, i.v., once) to the dogs of LPS and LPS+C groups. Statistically significant decreases in BChE and PON1 activities in LPS group were detected 24 and 48 h post injection, respectively. No statistically significant changes in BChE and PON1 activities at different times were detected in control, C, or LPS+C groups. In conclusion, the data obtained in present study revealed a decrease in serum BChE and PON1 activities in dogs during experimentally induced endotoxemia and that choline administration attenuates these changes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22000805/