Peer-reviewed veterinary case report
Heart injury marker levels in dogs with systemic inflammatory
By Hamacher, L et al.·Published in Journal of veterinary internal medicine·2015·Department of Clinical Veterinary Medicine, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Serum cardiac troponin I concentrations in dogs with systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of 60 dogs with systemic inflammatory response syndrome (SIRS) were studied to see how well measuring cardiac troponin I (cTnI) could predict their chances of survival. The dogs that survived had much lower levels of cTnI in their blood compared to those that did not make it. While measuring cTnI at different times did not provide more useful information than a single test at admission, higher cTnI levels were linked to a worse outcome. This suggests that if your dog is diagnosed with SIRS, a higher cTnI level could indicate a more serious condition.
People also search for: dog SIRS symptoms · high troponin levels in dogs · dog heart problems prognosis
Abstract
BACKGROUND: Myocardial injury can be detected by cardiac troponin I (cTnI) concentration, which appears to be a predictor of short-term death in critically ill patients. It is unknown if the best prognostic indicator of short-term survival is cTnI measurement at admission or at later time points. HYPOTHESIS/OBJECTIVES: Measuring cTnI with a high-sensitivity (HS) test at different time points after admission may be a better short-term prognostic indicator than a single cTnI measurement at admission in dogs with systemic inflammatory response syndrome (SIRS). ANIMALS: Prospective, observational clinical study of 60 dogs with SIRS. METHODS: Cardiac troponin I concentration was measured in 133 serum samples, collected at days 1, 2, 3, and 5. Additionally, the acute patient physiologic and laboratory evaluation (APPLE) fast score was evaluated at admission. Prognostic capabilities of cTnI measurement and APPLE fast score for 28-day mortality were assessed by receiver operating characteristic curve analysis. RESULTS: Forty-one dogs with SIRS that survived 28 days had significantly lower serum cTnI concentrations at admission (median, 0.09 ng/mL; P = .004) and at the peak time point (median, 0.23 ng/mL; P = .01) compared to 19 nonsurvivors (median at admission, 0.63 ng/mL; median at peak, 1.22 ng/mL). Area under the curve to predict survival, using cTnI was similar at admission (0.732) and at peak (0.708), and was 0.754 for the APPLE fast score. CONCLUSIONS AND CLINICAL IMPORTANCE: Increased cTnI concentration in dogs with SIRS is associated with poor outcome. Daily follow-up measurement of cTnI concentration provides no additional prognostic information for short-term mortality.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25619514/