Peer-reviewed veterinary case report
Blood tests to track acute pancreatitis in dogs during treatment
By Kirstin M. Keany et al.·Published in Journal of Veterinary Internal Medicine·2021·MedVet New Orleans, Louisiana and MedVet Mandeville, Louisiana USA, GB·View original on DOAJ →
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Original publication title: Serum concentrations of canine pancreatic lipase immunoreactivity and C‐reactive protein for monitoring disease progression in dogs with acute pancreatitis
- Species:
- dog
Plain-English summary
Thirteen dogs with acute pancreatitis, a condition causing severe abdominal pain and vomiting, were hospitalized to monitor their recovery. The veterinarians measured levels of pancreatic lipase and C-reactive protein in their blood to see if these could help track their progress. The results showed that dogs with higher activity scores tended to have better outcomes, and the blood tests correlated with their recovery. Most of the dogs (11 out of 13) recovered and were discharged, suggesting that these blood tests could be useful for monitoring dogs with this serious condition.
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Abstract
Abstract Background Reliable biomarkers for monitoring disease progression and management in dogs with acute pancreatitis have not been described. Objective To determine if serum concentrations of canine pancreatic lipase immunoreactivity (cPLI) and C‐reactive protein (CRP) can be used as biomarkers for disease progression in hospitalized dogs with acute pancreatitis. Animals Thirteen hospitalized dogs with acute pancreatitis diagnosed based on clinical signs, serum cPLI concentrations, and imaging findings were enrolled. Methods Serum cPLI and CRP concentrations were determined before and then daily during hospital management and 1 week after hospital discharge. Modified canine activity index (MCAI) and canine acute pancreatitis clinical severity index (CAPCSI) scores were calculated daily for each patient while hospitalized. Results The MCAI scores (P = .03) but not CAPCSI scores (P = .31) were significantly different between dogs that survived to discharge (n = 11) and those that did not (n = 2). Serum cPLI concentration was positively correlated with MCAI (rho = 0.42; P = .01). Serum CRP concentration also was positively correlated with the MCAI (rho = 0.42, P = .01). Conclusions Serum cPLI and possibly CRP could be used as objective biomarkers for clinical changes in hospitalized dogs with acute pancreatitis. Additional studies involving larger numbers of dogs would be warranted to evaluate the broader impact of these findings.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1111/jvim.16218