Peer-reviewed veterinary case report
Tracking pancreatitis in dogs using blood tests for pancreatic lipase
By Keany, Kirstin M et al.·Published in Journal of veterinary internal medicine·2021·MedVet New Orleans, United States·View original on PubMed →
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Original publication title: Serum concentrations of canine pancreatic lipase immunoreactivity and C-reactive protein for monitoring disease progression in dogs with acute pancreatitis.
- Species:
- dog
Plain-English summary
A group of 13 dogs with acute pancreatitis (a serious inflammation of the pancreas) were hospitalized to monitor their condition using specific blood tests. Researchers measured levels of canine pancreatic lipase immunoreactivity (cPLI) and C-reactive protein (CRP) to see if these could help track the disease's progress. They found that higher cPLI and CRP levels were linked to better activity scores in the dogs, suggesting these tests could be useful for monitoring recovery. Most of the dogs (11 out of 13) survived their hospital stay, indicating that these biomarkers may help veterinarians assess treatment effectiveness.
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Abstract
BACKGROUND: Reliable biomarkers for monitoring disease progression and management in dogs with acute pancreatitis have not been described. OBJECTIVE: To determine if serum concentrations of canine pancreatic lipase immunoreactivity (cPLI) and C-reactive protein (CRP) can be used as biomarkers for disease progression in hospitalized dogs with acute pancreatitis. ANIMALS: Thirteen hospitalized dogs with acute pancreatitis diagnosed based on clinical signs, serum cPLI concentrations, and imaging findings were enrolled. METHODS: Serum cPLI and CRP concentrations were determined before and then daily during hospital management and 1 week after hospital discharge. Modified canine activity index (MCAI) and canine acute pancreatitis clinical severity index (CAPCSI) scores were calculated daily for each patient while hospitalized. RESULTS: The MCAI scores (P = .03) but not CAPCSI scores (P = .31) were significantly different between dogs that survived to discharge (n = 11) and those that did not (n = 2). Serum cPLI concentration was positively correlated with MCAI (rho = 0.42; P = .01). Serum CRP concentration also was positively correlated with the MCAI (rho = 0.42, P = .01). CONCLUSIONS: Serum cPLI and possibly CRP could be used as objective biomarkers for clinical changes in hospitalized dogs with acute pancreatitis. Additional studies involving larger numbers of dogs would be warranted to evaluate the broader impact of these findings.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34250650/