Peer-reviewed veterinary case report
Serum concentrations of cortisol and cortisone in healthy dogs and dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
- Journal:
- The Veterinary record
- Year:
- 2008
- Authors:
- Sieber-Ruckstuhl, N S et al.
- Affiliation:
- Clinic for Small Animal Internal Medicine
- Species:
- dog
Plain-English summary
In a study involving 19 healthy dogs and 13 dogs with pituitary-dependent hyperadrenocorticism (a condition where the body produces too much cortisol), researchers looked at levels of cortisol and cortisone in the blood before and after an injection of a hormone called ACTH. They found that the dogs with this condition had much higher levels of both cortisol and cortisone compared to the healthy dogs. After treating the dogs with a medication called trilostane, their cortisol and cortisone levels decreased significantly, although the drop in cortisone was not as large as the drop in cortisol. Overall, the treatment with trilostane was effective in lowering the hormone levels in dogs with this condition.
Abstract
The serum concentrations of cortisol and cortisone were measured in 19 healthy dogs and in 13 dogs with pituitary-dependent hyperadrenocorticism (PDH) before and one hour after an injection of synthetic adrenocorticotropic hormone (ACTH). In the dogs with pdh, the cortisol and cortisone concentrations were measured before and after one to two weeks and three to seven weeks of treatment with trilostane. The dogs with PDH had significantly higher baseline and poststimulation concentrations of cortisol and cortisone, and higher baseline cortisol:cortisone ratios than the healthy dogs. During the treatment with trilostane, the poststimulation cortisol, the baseline and poststimulation cortisone concentrations, and the baseline and poststimulation cortisol:cortisone ratios decreased significantly. The decrease in poststimulation cortisone was significantly smaller than the decrease in cortisol.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18931355/