Peer-reviewed veterinary case report
Cortisol and cortisone levels in dogs treated with trilostane
By Sieber-Ruckstuhl, N S et al.·Published in The Veterinary record·2008·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Serum concentrations of cortisol and cortisone in healthy dogs and dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
- Species:
- dog
Plain-English summary
A group of dogs with pituitary-dependent hyperadrenocorticism (a condition causing excessive hormone production) had their cortisol and cortisone levels tested before and after treatment with a medication called trilostane. These dogs showed higher hormone levels compared to healthy dogs. After starting trilostane, their hormone levels decreased significantly, indicating that the treatment was effective in managing their condition. However, the reduction in cortisone was not as pronounced as that of cortisol.
People also search for: dog Cushing's disease treatment · trilostane for dogs · high cortisol levels in dogs
Abstract
The serum concentrations of cortisol and cortisone were measured in 19 healthy dogs and in 13 dogs with pituitary-dependent hyperadrenocorticism (PDH) before and one hour after an injection of synthetic adrenocorticotropic hormone (ACTH). In the dogs with pdh, the cortisol and cortisone concentrations were measured before and after one to two weeks and three to seven weeks of treatment with trilostane. The dogs with PDH had significantly higher baseline and poststimulation concentrations of cortisol and cortisone, and higher baseline cortisol:cortisone ratios than the healthy dogs. During the treatment with trilostane, the poststimulation cortisol, the baseline and poststimulation cortisone concentrations, and the baseline and poststimulation cortisol:cortisone ratios decreased significantly. The decrease in poststimulation cortisone was significantly smaller than the decrease in cortisol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18931355/