Peer-reviewed veterinary case report
Gabapentin blood levels in cats with chronic kidney disease
By Quimby, Jessica M et al.Ā·Published in Journal of feline medicine and surgeryĀ·2022Ā·Department of Veterinary Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Serum concentrations of gabapentin in cats with chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were given gabapentin, a medication often used for pain relief, to see how their bodies processed it compared to healthy cats. The study found that the CKD cats had much higher levels of gabapentin in their blood after receiving a lower dose than what healthy cats received. This suggests that cats with kidney issues may need a smaller dose of gabapentin to avoid potential side effects. If your cat has CKD and needs pain management, talk to your vet about adjusting the gabapentin dosage.
People also search for: cat chronic kidney disease treatment Ā· gabapentin dosage for cats Ā· pain relief for cats with kidney disease
Abstract
OBJECTIVES: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. METHODS: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 8, 12, 24 and 36 h via a jugular catheter. Serum gabapentin concentrations were measured using liquid chromatography coupled to tandem mass spectrometry. Non-compartmental pharmacokinetic analysis was performed. The same five healthy cats plus 25 cats with stable International Renal Interest Society stage 2 (n = 14) and 3 (n = 11) CKD were enrolled in a limited sampling study. Cats in both groups received a single 10 mg/kg dose of gabapentin, and serum gabapentin concentrations and compliance scores were obtained 3 and 8 h post-administration. RESULTS: Cats with CKD had significantly higher dose-normalized serum gabapentin concentrations than normal cats at 3 h ( = 0.0012 CKD vs normal 10 mg/kg; = 0.008 CKD vs normal 20 mg/kg) and 8 h (<0.0001 CKD vs normal 10 mg/kg;<0.0001 CKD vs normal 20 mg/kg). Both 3 and 8 h dose-normalized serum gabapentin concentrations were significantly correlated with serum creatinine (3 h: = 0.03, = 0.39; 8 h: = 0.001, = 0.57) and symmetric dimethylarginine (3 h: = 0.03, = 0.41; 8 h: = 0.007, = 0.48). There was a significant correlation between 3 h serum gabapentin concentrations and compliance scores ( = 0.0002, = 0.68). CONCLUSIONS AND RELEVANCE: Cats with CKD that received 10 mg/kg of gabapentin had significantly higher dose-normalized serum concentrations than normal cats that received 20 mg/kg, supporting the need to dose-reduce in this patient population.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35195476/