Peer-reviewed veterinary case report
Blood test shows high PIIINP in dogs with liver fibrosis
By Glińska-Suchocka, K et al.·Published in Polish journal of veterinary sciences·2016·View original on PubMed →
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Original publication title: Serum concentrations of PIIINP aminopeptide in dogs with liver fibrosis.
- Species:
- dog
Plain-English summary
A group of 20 dogs aged 7 to 15 years, with varying breeds and genders, were tested for liver fibrosis, a condition where the liver becomes scarred. Researchers found that dogs with early stages of liver fibrosis had five times higher levels of a specific protein (PIIINP) in their blood compared to healthy dogs. In more advanced stages of fibrosis, the protein levels were ten times higher than those in healthy dogs. This suggests that measuring PIIINP levels could be a helpful, non-invasive way for vets to diagnose and assess the severity of liver fibrosis in dogs.
People also search for: dog liver fibrosis symptoms · elevated PIIINP in dogs · liver disease diagnosis in dogs
Abstract
The aim of the study was to evaluate the serum concentration of the type III procollagen aminopeptide in dogs, and to assess its utility in the diagnosis of liver fibrosis. The study was carried out on 20 dogs of different breeds and of both genders, between 7 and 15 years old. Based on the results of the histopathological examination and the evaluation of the degree of liver fibrosis, the dogs were divided into five groups. The mean serum PIIINP concentration in the group of dogs with stage 1 and 2 liver fibrosis (groups 2 and 3) was five-fold higher than in healthy dogs (group 1). In turn, the mean PIIINP concentration in the group of dogs with stage 3 (group 4) and stage 4 (group 5) fibrosis was 10-fold higher than that of the control group (group 1). Based on the results, we found that the serum PIIINP concentration correlated with the degree of liver fibrosis, assessed based on a histopathological examination. Therefore, PIIINP serum concentration tests may be a promising non-invasive diagnostic technique that could be used in veterinary hepatology to assess the degree of liver fibrosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27487511/