Peer-reviewed veterinary case report
Blood and stool tests to tell infectious from non-infectious diarrhea
By Mehmet Maden & Erdem Gülersoy·Published in Veterinary Medicine and Science·2023·Department of Internal Medicine Veterinary Faculty Selcuk University Konya Turkey, GB·View original on DOAJ →
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Original publication title: Serum/Faecal S100A12, CRP and lactoferrin can be used to distinguish ınfectious and non‐ınfectious canine diarrhoea
- Species:
- dog
Plain-English summary
A group of dogs with diarrhea was tested to find out if certain blood and stool markers could help tell the difference between infectious diarrhea (caused by germs) and non-infectious diarrhea (often due to diet). The study found that dogs with infectious diarrhea had higher levels of specific markers in their blood and stool compared to healthy dogs and those with dietary issues. These markers, like S100A12 and C-reactive protein (CRP), can help veterinarians diagnose the type of diarrhea and decide on the best treatment. Understanding these differences can lead to better care for dogs suffering from diarrhea.
People also search for: dog diarrhea treatment · how to tell if dog diarrhea is infectious · dog stool test for diarrhea
Abstract
Abstract Objectives This study aimed to evaluate the diagnostic efficacies of selected inflammatory and intestinal biomarkers in cases of infectious and non‐infectious diarrhoea in dogs. Methods A total of 60 dogs, 12 healthy (Control Group) and 48 with diarrhoea were used. Viral, Bacterial, Parasitic (infectious) and Nutritional diarrhoea (non‐infectious) subgroups (n: 12) were formed according to the aetiology, on the basis of clinical and laboratory examinations. Selected inflammatory and intestinal biomarkers (Calgranulin, S100A12; Lactoferrin, LCTF; C‐reactive protein, CRP) were measured both in serum and faecal samples. Results Compared to the Control and Nutritional Diarrhoea groups, the infectious diarrhoea groups had higher serum S100A12, LCTF, CRP, blood urea nitrogen, creatinine (CR), alanine transaminase and alkaline phosphatase, and lower glucose (GLU), sodium (Na) and potassium (K) concentrations (p < 0.05); Viral and Parasitic Diarrhoea groups had lower serum albumin (ALB) and total protein (TP) concentrations (p < 0.05). Faecal S100A12, LCTF and CRP concentrations were higher in infectious diarrhoea groups compared to the Control and Nutritional Diarrhoea groups (p < 0.05). Faecal LCTF and CRP concentrations were higher in the Bacterial Diarrhoea group than in the Viral and Parasitic Diarrhoea groups (p < 0.05). Clinical significance It was determined that serum (area under curve, AUC: 0.842 and 0.956) and faecal (AUC: 0.975 and 0.786) S100A12 and CRP concentrations in viral diarrhoea; serum (AUC: 0.956) and faecal (AUC: 0.992) LCTF concentrations in bacterial diarrhoea have diagnostic values in the diagnosis of the presence of intestinal inflammation and damage and can be used in the differential diagnosis of infectious and non‐infectious diarrhoea.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1002/vms3.1245