Peer-reviewed veterinary case report
Blood and stool tests can tell infectious from non-infectious
By Maden, Mehmet & Gülersoy, Erdem·Published in Veterinary medicine and science·2023·Department of Internal Medicine·View original on PubMed →
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Original publication title: Serum/Faecal S100A12, CRP and lactoferrin can be used to distinguish ınfectious and non-ınfectious canine diarrhoea.
- Species:
- dog
Plain-English summary
A group of 48 dogs with diarrhea was studied to find out how to tell if their condition was caused by an infection or something else, like diet. Researchers measured certain markers in the dogs' blood and stool to see which ones were higher in cases of infectious diarrhea. They found that specific markers like S100A12 and C-reactive protein (CRP) were significantly higher in dogs with infectious diarrhea compared to healthy dogs and those with dietary issues. This means that these tests could help veterinarians diagnose the cause of diarrhea more accurately, leading to better treatment options for affected dogs.
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Abstract
OBJECTIVES: This study aimed to evaluate the diagnostic efficacies of selected inflammatory and intestinal biomarkers in cases of infectious and non-infectious diarrhoea in dogs. METHODS: A total of 60 dogs, 12 healthy (Control Group) and 48 with diarrhoea were used. Viral, Bacterial, Parasitic (infectious) and Nutritional diarrhoea (non-infectious) subgroups (n: 12) were formed according to the aetiology, on the basis of clinical and laboratory examinations. Selected inflammatory and intestinal biomarkers (Calgranulin, S100A12; Lactoferrin, LCTF; C-reactive protein, CRP) were measured both in serum and faecal samples. RESULTS: Compared to the Control and Nutritional Diarrhoea groups, the infectious diarrhoea groups had higher serum S100A12, LCTF, CRP, blood urea nitrogen, creatinine (CR), alanine transaminase and alkaline phosphatase, and lower glucose (GLU), sodium (Na) and potassium (K) concentrations (p < 0.05); Viral and Parasitic Diarrhoea groups had lower serum albumin (ALB) and total protein (TP) concentrations (p < 0.05). Faecal S100A12, LCTF and CRP concentrations were higher in infectious diarrhoea groups compared to the Control and Nutritional Diarrhoea groups (p < 0.05). Faecal LCTF and CRP concentrations were higher in the Bacterial Diarrhoea group than in the Viral and Parasitic Diarrhoea groups (p < 0.05). CLINICAL SIGNIFICANCE: It was determined that serum (area under curve, AUC: 0.842 and 0.956) and faecal (AUC: 0.975 and 0.786) S100A12 and CRP concentrations in viral diarrhoea; serum (AUC: 0.956) and faecal (AUC: 0.992) LCTF concentrations in bacterial diarrhoea have diagnostic values in the diagnosis of the presence of intestinal inflammation and damage and can be used in the differential diagnosis of infectious and non-infectious diarrhoea.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37688789/