Peer-reviewed veterinary case report
FGF-23 levels in young and adult cats with kidney disease
By Miyakawa, Hirosumi et al.·Published in Journal of feline medicine and surgery·2022·Nippon Veterinary and Life Science University, Japan·View original on PubMed →
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Original publication title: Serum fibroblast growth factor-23 concentrations in young and mature adult cats with chronic kidney disease.
- Species:
- cat
Plain-English summary
A study found that young and mature adult cats with chronic kidney disease (CKD) had higher levels of a protein called FGF-23 in their blood compared to healthy cats. This increase was noticeable even in the early stages of CKD and was linked to other markers of mineral metabolism in the body. The findings suggest that monitoring FGF-23 levels could help veterinarians assess kidney health in cats. If your cat has CKD, discussing these results with your vet might provide insights into managing their condition.
People also search for: cat chronic kidney disease symptoms · FGF-23 levels in cats · cat kidney disease treatment options
Abstract
OBJECTIVES: The aim of this study was to investigate serum fibroblast growth factor (FGF)-23 concentrations in young and mature adult cats with chronic kidney disease (CKD). METHODS: The present study retrospectively investigated the serum samples and medical records of 1-8-year-old clinically healthy cats (control group, n = 7) and cats with CKD (n = 54). Cats with CKD were divided into four stages based on serum creatinine concentrations, according to the International Renal Interest Society (IRIS) CKD guidelines. Serum FGF-23 concentrations were compared between cats in the control group, IRIS stages 1, 2 and 3-4 CKD. Continuous variables were analysed using correlations and multiple linear regression. RESULTS: Serum FGF-23 concentrations were significantly higher in cats with IRIS stages 1, 2 and 3-4 CKD, compared with those in the control group ( = 0.02, P = 0.002 and = 0.002, respectively). Additionally, serum FGF-23 concentrations in cats with IRIS stages 3-4 CKD had higher serum FGF-23 concentrations than those with IRIS stages 1 and 2 CKD ( = 0.04 and = 0.02, respectively). In the multiple linear regression analysis, serum urea nitrogen concentration, serum phosphorus concentration and blood ionised calcium concentration were independent variables predicting serum FGF-23 concentration. CONCLUSIONS AND RELEVANCE: Serum FGF-23 concentrations in younger cats with CKD increased in early-stage CKD and were associated with mineral metabolic markers, as also occurs in geriatric cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34431737/