Gastrin levels in dogs with primary hyperparathyroidism

Abstract

BACKGROUND: Hypercalcemia has been associated with hypergastrinemia in humans. Hypergastrinemia could be responsible for gastrointestinal (GI) signs in dogs with primary hyperparathyroidism (PHPT). HYPOTHESIS/OBJECTIVES: (a) Determine whether hypergastrinemia occurs in dogs with PHPT, (b) assess for potential correlations among ionized calcium (iCa), parathyroid hormone (PTH), and serum gastrin concentrations, and (c) determine whether gastrin concentrations decrease after management of PHPT. ANIMALS: Phase 1: 151 client-owned dogs at the time of PHPT diagnosis, Phase 2: 24 dogs that underwent treatment for PHPT. METHODS: Dogs with azotemia, concurrent disease, or those receiving acid suppressants were excluded. Twenty-four treated dogs had baseline and repeat quantification of serum gastrin, PTH, and iCa concentrations 4&#x2009;weeks after treatment. The effect of treatment on gastrin, iCa, and PTH concentrations was assessed using Wilcoxon signed rank sum tests. Fisher exact testing was used to compare the proportion of dogs with hypergastrinemia in dogs with and without GI signs. RESULTS: Twenty-seven of 151 PHPT dogs (17.9%) had increased pre-treatment serum gastrin concentrations (median, 45.0&#x2009;ng/L; interquartile range [IQR], 20.0&#x2009;ng/L). Gastrin concentrations were not correlated with iCa (P&#x2009;=&#x2009;.92) or PTH (P&#x2009;=&#x2009;.60). Treatment of PHPT decreased PTH (P&#x2009;<&#x2009;.001) and iCa concentrations (P&#x2009;<&#x2009;.001), but not gastrin concentrations (P&#x2009;=&#x2009;.15). The proportion of dogs with hypergastrinemia with and without GI signs did not differ (P&#x2009;=&#x2009;1.00). CONCLUSIONS AND CLINICAL IMPORTANCE: Mild increases in serum gastrin concentrations may be seen in dogs with PHPT, but this finding is independent of the presence of GI signs.