Peer-reviewed veterinary case report
Blood test for brain disease necrotizing meningoencephalitis in Pug
By Miyake, Hizuru et al.·Published in The Journal of veterinary medical science·2013·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Serum glial fibrillary acidic protein as a specific marker for necrotizing meningoencephalitis in Pug dogs.
- Species:
- dog
Plain-English summary
A group of Pug dogs diagnosed with necrotizing meningoencephalitis (NME), a serious brain condition, had their blood tested for a specific protein called GFAP. The results showed that only Pugs with NME had higher levels of this protein, which could help vets diagnose this condition more accurately in Pugs compared to other breeds. However, the GFAP levels did not relate to the dogs' age or how long they survived after diagnosis. This finding suggests that measuring GFAP in the blood could be a helpful tool for identifying NME in Pugs.
People also search for: Pug dog brain disease symptoms · necrotizing meningoencephalitis treatment · elevated GFAP in dogs · Pug health issues · how to diagnose NME in dogs
Abstract
To evaluate the ability of serum glial fibrillary acidic protein (GFAP) concentration as a diagnostic marker for canine central nervous system (CNS) disorders, sera from dogs with various CNS (n=47) and non-CNS (n=56) disorders were measured for GFAP by using an ELISA kit. Healthy Beagles (n=15) and Pug dogs (n=12) were also examined as controls. Interestingly, only Pug dogs with necrotizing meningoencephalitis (NME) showed elevated serum GFAP concentrations (<0.01 to 1.14 ng/ml), while other breeds of dogs with NME did not. Among the Pug dogs with NME, serum GFAP concentrations did not correlate with their clinical features, such as ages or survival times. Our data indicate the usefulness of serum GFAP as a novel marker for Pug dogs with NME.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23856761/