Peer-reviewed veterinary case report
IgE antibodies to carbohydrate allergens in healthy and itchy dogs
By Piccione, Michelle L & DeBoer, Douglas J·Published in Veterinary dermatology·2019·Department of Medical Sciences, United States·View original on PubMed →
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Original publication title: Serum IgE against cross-reactive carbohydrate determinants (CCD) in healthy and atopic dogs.
- Species:
- dog
Plain-English summary
A study looked at the presence of certain antibodies (anti-CCD IgE) in both healthy dogs and those with skin allergies (atopic dermatitis). They found that about 17% of the allergic dogs and 13% of the healthy dogs had these antibodies, with all of them showing strong reactions to grass pollen. This suggests that the presence of these antibodies might not be a clear indicator of allergy in dogs. More research is needed to understand what this means for diagnosing and treating skin problems in dogs.
People also search for: dog skin allergies treatment · why is my dog itching · dog allergy testing results
Abstract
BACKGROUND: Cross-reactive carbohydrate determinants (CCD) are Immunoglobulin E (IgE)-binding carbohydrate structures common to plant and insect species. In people, anti-CCD IgE is thought to be clinically irrelevant, but to have the potential to confound serological IgE test interpretations. Previous studies reported the detection of anti-CCD IgE in 24-73% of atopic dog sera; prevalence in healthy dogs has not been reported. OBJECTIVE: To compare the prevalence of anti-CCD IgE in a group of healthy and atopic dogs. ANIMALS: Sera from 61 healthy dogs and 101 dogs with a clinical diagnosis of atopic dermatitis were analyzed for IgE against CCD. METHODS AND MATERIALS: Sera were analyzed for the presence of anti-CCD IgE and IgE against environmental allergens using a commercial multiplex allergen-specific IgE assay. RESULTS: Anti-CCD IgE was detected in 17 of 101 (16.8%) atopic dog sera and eight of 61 (13.1%) healthy dog sera (P = 0.65, Fisher's exact test). All healthy and atopic dogs with anti-CCD IgE had strong reactivity to grass pollens. CONCLUSIONS AND CLINICAL IMPORTANCE: A similar prevalence of anti-CCD IgE was found in healthy and atopic dogs. Further investigation is warranted to determine the clinical significance of anti-CCD IgE antibodies in dogs, how they are best detected and if blocking these antibodies during diagnostic testing has clinical value.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31642119/