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Peer-reviewed veterinary case report

Insulin-like growth factor 1 levels in healthy and hypothyroid dogs

By Jaillardon, Laetitia et al.Ā·Published in Veterinary journal (London, England : 1997)Ā·2011Ā·Department of Biology, FranceĀ·View original on PubMed ā†’

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Original publication title: Serum insulin-like growth factor type 1 concentrations in healthy dogs and dogs with spontaneous primary hypothyroidism.

Species:
dog
Hypothyroidism in dogsAppetite & weightDogs

Plain-English summary

A group of dogs with primary hypothyroidism (a condition where the thyroid gland doesn't produce enough hormones) showed higher levels of insulin-like growth factor type 1 (IGF-1) compared to healthy dogs. This study looked at 220 hypothyroid dogs and 495 healthy dogs, measuring their IGF-1 levels in relation to their body weight. The results indicated that as body weight increased, IGF-1 levels also increased in the hypothyroid dogs. However, it's uncertain whether the higher IGF-1 levels are directly caused by hypothyroidism or if they are a result of weight gain that often accompanies this condition.

People also search for: dog hypothyroidism symptoms Ā· insulin-like growth factor in dogs Ā· dog weight gain hypothyroidism

Abstract

Circulating insulin-like growth factor type 1 (IGF-1) concentrations in dogs have been correlated with standard breed bodyweight (SBBW or breed size). Thyroid and somatotropic functions, which have common effects and regulatory mechanisms, were investigated in hypothyroid dogs. IGF-1 was measured in 495 adult healthy dogs (N) and in 220 primary hypothyroid dogs (HOT) with clinical and biological signs of primary hypothyroidism. IGF-1 was determined as a function of SBBW (kg): &#x2264;15 (group A); 15<SBBW&#x2264;25 (group B); 25<SBBW&#x2264;40 (group C); and >40 (group D). In HOT dogs, median fT4 and c-TSH values were 9pmol/L and 1.5ng/mL, respectively. A significant correlation between bodyweight (BW) and IGF-1 was observed in both HOT and N dogs. The median IGF-1 value (ng/mL) was significantly higher (P<0.01) in HOT dogs compared to N in groups B, C and D (230 vs. 182; 316 vs. 230; 606 vs. 306 respectively). In conclusion, IGF-1 concentration should be interpreted in the context of SBBW in dogs and increases in spontaneous primary hypothyroidism. However, it remains unclear if this association is directly due to hypothyroidism or is the result of the weight gain accompanying hypothyroidism.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21546289/

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