Peer-reviewed veterinary case report
Blood test for tracking aggressive lymphoma in dogs during chemo
By R.C. Bitencourt et al.·Published in Veterinary Sciences·2026·View original on Semantic Scholar →
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Original publication title: Serum Lactate Dehydrogenase as a Biomarker of Disease Burden and Chemotherapy Response in Canine High-Grade Multicentric Lymphoma
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with high-grade lymphoma, a common type of cancer, had their blood tested for an enzyme called lactate dehydrogenase (LDH). The results showed that dogs with lymphoma had much higher LDH levels compared to healthy dogs. After starting chemotherapy, those that responded well saw their LDH levels drop significantly, often returning to normal in dogs that went into complete remission. This simple blood test can help veterinarians track how well the treatment is working and monitor the disease's impact on the dog.
People also search for: dog lymphoma treatment · high LDH levels in dogs · chemotherapy response in dogs with cancer
Abstract
Simple Summary Lymphoma is a common type of cancer in dogs. Blood tests that track the disease during treatment are helpful for veterinarians. One such test measures an enzyme called lactate dehydrogenase (LDH), which can be higher in cancer cases, but its significance in dogs with lymphoma is not fully explored. This study found that dogs with aggressive lymphoma had much higher LDH levels compared to healthy dogs. After chemotherapy, LDH levels dropped, especially in dogs that responded well to treatment. Dogs that went into complete remission (CR) often had their LDH levels return to normal. Additionally, dogs with lower platelet counts had higher LDH levels at diagnosis and larger decreases during treatment. Overall, LDH is a simple, inexpensive blood test that can help monitor disease burden and treatment response in dogs with high-grade lymphoma.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/41600749