Peer-reviewed veterinary case report
Higher blood oxidative stress in older dogs with cataracts
By Madany, J·Published in Polish journal of veterinary sciences·2016·View original on PubMed →
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Original publication title: Serum malondialdehyde level and activity of total antioxidant status of dogs with age-related cataract.
- Species:
- dog
Plain-English summary
A group of older dogs, aged 10 to 16 years, with age-related cataracts were found to have higher levels of a substance called malondialdehyde (MDA) in their blood, which indicates increased oxidative stress. At the same time, these dogs showed lower levels of total antioxidant status (TAS), meaning their bodies had a reduced ability to fight off damage from free radicals. This suggests that oxidative stress may play a role in the development of cataracts in older dogs. While the study didn't provide specific treatments, it highlights the importance of monitoring older dogs for eye problems and considering antioxidant support as part of their care.
People also search for: dog cataracts treatment · older dog eye problems · antioxidants for dogs with cataracts
Abstract
STUDY OBJECTIVE: determination of malondialdehyde (MDA) level and total antioxidant status (TAS) in the serum of dogs with age-related cataract. MATERIAL AND METHODS: Forty dogs, 10-16 years of age, which were diagnosed with age-related cataract were examined. The control group consisted of 12 dogs, 8-13 years of age, without cataract. MDA was determined using a Perkin-Elmer LS 30 luminescence spectrometer using the method with thiobarbituric acid (TBA). TAS was determined using the colorimetric method with a set of Randox Total Antioxidant Status reagents. RESULTS: The results show a higher level of MDA with statistically significant difference and lower activity of TAS in the serum of dogs with age-related cataract. CONCLUSIONS: The results obtained indicate higher systemic lipid peroxidation and weakening of the general defense system in dogs with age-related cataract. These results suggest that such conditions may have an effect on the development of age-related cataract and are consistent with the theory of free radical age-related cataract development.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27487520/