Peer-reviewed veterinary case report
Oxidant and antioxidant levels in dogs with new epilepsy
By Radaković, Milena et al.·Published in Research in veterinary science·2023·Department of Pathophysiology·View original on PubMed →
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Original publication title: Serum oxidant-antioxidant status and butyrylcholinesterase activity in dogs with idiopathic epilepsy - A pilot study.
- Species:
- dog
Plain-English summary
A group of 15 dogs with newly diagnosed idiopathic epilepsy (a common neurological condition causing seizures) had their blood tested to check for signs of oxidative stress, which can affect their health. The results showed that these dogs had higher levels of certain oxidants and lower levels of antioxidants compared to healthy dogs. Specifically, the dogs with epilepsy had reduced activity of butyrylcholinesterase, an enzyme that helps protect the brain. Understanding these changes in blood chemistry may help veterinarians better manage epilepsy in dogs.
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Abstract
Oxidative stress plays an important role in pathogenesis of idiopathic epilepsy (IE). Although IE is the most common neurological condition, oxidant-antioxidant status in epileptic dogs is still unknown. The aim of this study is to evaluate the serum oxidant-antioxidant status in dogs with newly diagnosed IE. The status in 15 dogs with IE and 15 healthy dogs is estimated through spectrophotometric determination of two oxidant markers: advanced oxidation protein products-albumin index (AOPP) and thiobarbituric acid reactive substances (TBARS); and three antioxidant markers: total thiols (R-SH) level, glutathione (GSH) level, and paraoxonase-1 (PON-1) activity. Also, butyrylcholinesterase (BChE) activity is assessed in both groups of dogs. Higher AOPP is observed in the dogs with newly diagnosed IE, while TBARS level shows no difference when compared to the healthy dogs. In contrast, lower levels of antioxidants (R-SH, GSH, and PON-1) and BChE activity are found in the dogs with IE. No significant differences are observed in the oxidant and antioxidant markers and BChE activity across the investigated IE cases with focal and generalized seizures. Our findings provide evidence that dogs with IE are characterized by an impaired serum oxidant-antioxidant balance and lower BChE activity, which may contribute to a better understanding of IE pathogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37939632/