Peer-reviewed veterinary case report
Serum oxytocinase activity is related to tumor growth parameters in N-methyl nitrosourea induced rat breast cancer.
- Journal:
- Life sciences
- Year:
- 2004
- Authors:
- Carrera, M P et al.
- Affiliation:
- Departamento de Ciencias de la Salud · Spain
- Species:
- rodent
Abstract
Oxytocinase has been reported to hydrolyse the peptide hormone oxytocin (OT). We have previously described changes in oxytocinase activity in human breast cancer, where a highly significant increase occurred in tumoral tissue. In the present work, we analysed oxytocinase activity in serum of rats with breast cancer induced by N-methyl-nitrosourea (NMU). We also correlated these data with the number and size of tumors and the body weight of the animals to evaluate the putative value of this activity as a biological marker of the disease. Our results confirm the involvement of OT in carcinogenesis and suggest a mayor role for oxytocinase activity in the development of breast cancer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15234194/