Peer-reviewed veterinary case report
Changes in blood enzyme and fat levels in Dachshunds with mitral
By Kulka, M et al.·Published in Polish journal of veterinary sciences·2017·Department of Pathology and Veterinary Diagnostics·View original on PubMed →
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Original publication title: Serum paraoxonase 1 activity and lipid metabolism parameter changes in Dachshunds with chronic mitral valve disease. Assessment of its diagnostic usefulness.
- Species:
- dog
Plain-English summary
A group of Dachshunds with chronic mitral valve disease (a heart condition) showed changes in certain blood markers that could help diagnose the disease at different stages. In particular, the study found that dogs in the early stages (B1 and B2) had lower levels of a specific enzyme (PON1) compared to healthy dogs, while those in the later stage (C) had higher levels. Additionally, dogs in stages B2 and C had increased triglyceride levels, which could indicate worsening health. These findings suggest that monitoring PON1 levels could help veterinarians determine how advanced the heart disease is and guide treatment decisions.
People also search for: Dachshund heart disease symptoms · chronic mitral valve disease treatment · dog triglyceride levels high
Abstract
Chronic mitral valve disease, which is frequently diagnosed in Dachshunds, leads to structural, hemodynamic and redox state changes in dogs. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity and lipid metabolism in different disease stages. Standardized PON1 activity (PON1/HDL ratio) was lower in asymptomatic dogs, B1 and B2 Stages when compared to healthy ones and symptomatic Dachshunds in Stage C (ACVIM classfication). PON1 paraoxonase activity was elevated in Stage C dogs, with no changes found in PON1 activity towards phenyl acetate. Dachshunds in Stage B2 and C showed increased triglyceride levels, with no changes in cholesterol and lipoprotein concentration in comparison to healthy ones. Our data suggest that standardized PON1 activity changes could be used in laboratory diagnostics to differentiate the CMVD of affected asymptomatic (Stage B1 and B2) dogs from healthy (Stage A) and clinically affected (Stage C) dogs. Also, a standardized PON1 activity increase might be a prognostic progression signal of the disease to Stage C.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29611636/