Peer-reviewed veterinary case report
Serum paraoxonase 1 activity is low in dogs with acute pancreatitis
By Tvarijonaviciute, A et al.·Published in The Journal of small animal practice·2015·Departament de Medicina i Cirurgia Animals, Spain·View original on PubMed →
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Original publication title: Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs.
- Species:
- dog
Plain-English summary
A group of dogs with acute pancreatitis had lower levels of a specific enzyme called paraoxonase 1 compared to healthy dogs. This enzyme is linked to inflammation and can indicate how severe the pancreatitis is. The study found that as the severity of the disease increased, the levels of paraoxonase 1 decreased, while other markers like triglycerides and C-reactive protein increased. Understanding these changes can help veterinarians assess the condition of dogs with pancreatitis and tailor their treatment accordingly.
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Abstract
OBJECTIVES: Serum paraoxonase 1 is considered a marker of inflammation and oxidative damage. The aims of this study were to evaluate changes in serum paraoxonase 1 activity in dogs with acute pancreatitis, to correlate serum paraoxonase 1 activity and other analytes known to be altered in dogs with pancreatitis and to assess the relationship between serum paraoxonase 1 activity and disease severity in dogs with acute pancreatitis. MATERIALS AND METHODS: Retrospective analysis of dogs with acute pancreatitis and healthy dogs in which serum paraoxonase 1 activity was measured were compared. RESULTS: Median serum paraoxonase 1 activity was significantly lower in dogs with pancreatitis (n = 19) compared to healthy ones (n = 19). Serum paraoxonase 1 activity was negatively correlated with serum lipase and amylase activities, and C-reactive protein and haptoglobin concentrations and was positively correlated with total cholesterol and glucose concentration. Disease severity was negatively correlated with serum paraoxonase 1 activity and positively correlated with triglyceride and C-reactive protein concentration. CLINICAL SIGNIFICANCE: Serum paraoxonase 1 activity is lower in dogs with acute pancreatitis and together with triglyceride and C-reactive protein concentrations is a potential marker of disease severity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25395020/