Peer-reviewed veterinary case report
Serum Thymidine Kinase Activity: An Alternative to Histologic Markers of Cellular Proliferation in Canine Lymphoma
- Journal:
- Journal of Veterinary Internal Medicine
- Year:
- 2004
- Authors:
- Madewell, Bruce R
- Affiliation:
- University of California Davis Department of Surgical and Radiological Sciences School of Veterinary Medicine , CA 95616 e-mail: brmadewell@ucdavis.edu · United States
- Species:
- dog
Abstract
Abstract Thymidine kinase (TK) is a cellular enzyme which is involved in a salvage pathway of DNA synthesis. It is activated in the G1/S phase of the cell cycle, and its activity has been shown to correlate with the proliferative activity of tumor cells⃜Clin-ical studies have reported high serum TK concentrations in a variety of neoplasias. The majority of these studies concerned hematological malignancies. TK seems to be a useful marker in non-Hodgkins lymphoma, where it correlates with clinical stag-ing and provides marked prognostic information on (progres-sion-free) survival.
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Search related cases →Original publication: https://doi.org/10.1111/j.1939-1676.2004.tb02592.x