Peer-reviewed veterinary case report
Serum VEGF levels in dogs with soft tissue sarcoma
By de Queiroz, G Fernandes et al.·Published in Veterinary and comparative oncology·2013·Department of Animal Sciences, Brazil·View original on PubMed →
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Original publication title: Serum vascular endothelial growth factor in dogs with soft tissue sarcomas.
- Species:
- dog
Plain-English summary
A group of dogs with soft tissue sarcomas had their blood tested for a substance called vascular endothelial growth factor (VEGF), which is often linked to tumor growth. The study found that the VEGF levels in these dogs were similar to those in healthy dogs, but after the tumors were surgically removed, the VEGF levels decreased. Additionally, dogs with a specific type of tumor called hemangiopericytoma had higher VEGF levels compared to those with another type of tumor. This suggests that VEGF might play a role in how these tumors grow and develop.
People also search for: dog soft tissue sarcoma treatment · high VEGF levels in dogs · dog tumor surgery recovery
Abstract
This work aimed to evaluate serum vascular endothelial growth factor (VEGF) in 25 dogs with soft tissue sarcoma, and in 30 healthy dogs. Blood was collected once time from the control animals and three times, in the same way, from animals with sarcoma. Blood count was performed in the blood collected, and serum VEGF was measured by enzyme-linked immunosorbent assay quantitative method. Serum VEGF in control animals was similar to patients with soft tissue sarcoma. There was a reduction in serum VEGF after the sarcoma resection. There was positive correlation between serum VEGF and neutrophil counts, and negative between VEGF and hemoglobin content in animals with sarcoma. Animals with hemangiopericytoma showed higher serum VEGF levels compared to the patients with malignant peripheral nerve sheath. Circulating blood cells can contribute to elevate VEGF serum concentrations in dogs with soft tissue sarcomas and a possible role of VEGF in the angiogenesis of these tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22372675/