Peer-reviewed veterinary case report
Severe dog flu linked to high virus levels and immune response
By Lee, Yu-Na et al.·Published in Virology·2011·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Severe canine influenza in dogs correlates with hyperchemokinemia and high viral load.
- Species:
- dog
Plain-English summary
A group of dogs infected with canine influenza virus (CIV) showed severe breathing problems and respiratory illness. The virus caused significant inflammation in their lungs, leading to symptoms like coughing and difficulty breathing. Some dogs also developed anemia, possibly due to bleeding in the lungs. Understanding how the virus affects dogs can help veterinarians treat and manage these infections more effectively.
People also search for: dog coughing treatment · canine influenza symptoms · dog respiratory disease care
Abstract
Canine influenza virus (CIV) is an emerging pathogen that causes acute respiratory disease in dogs. To better understand the mechanism(s) responsible for the virulence of the virus, we conducted immunological, virological, clinical, and histopathological analyses in CIV-infected dogs. CIV replicated efficiently in the respiratory system of dogs and caused severe respiratory disease. Notably, the infection induced the marked elevation and sustained expression of chemokines that resulted in severe bronchointerstitial pneumonia with extensive neutrophil infiltration. In clinicopathological findings, CIV infection resulted in regenerative anemia, perhaps due to pulmonary hemorrhage. The observations indicate that active replication of CIV in the canine respiratory system results in intense inflammatory responses central to the pathogenesis of H3N2 CIV.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21632085/