Peer-reviewed veterinary case report
Dog with severe fungal lymph node and brain infection
By Magstadt, Drew R et al.·Published in Veterinary pathology·2018·1 Department of Veterinary Diagnostic and Production Animal Medicine, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Severe Disseminated Necrotizing and Granulomatous Lymphadenitis and Encephalitis in a Dog Due to Sporotrichum pruinosum (Teleomorph: Phanerochaete chrysosporium).
- Species:
- dog
Plain-English summary
A 9-year-old female mixed breed dog was brought to the vet because she suddenly stopped eating, was vomiting, and had a cough. After tests, the vet found a large mass in her chest and identified fungal organisms. Despite treatment, her condition worsened over the next eight months, leading to her being euthanized. A thorough examination after her passing revealed severe inflammation and fungal infection in her lymph nodes and brain. This case highlights a rare fungal infection that can affect dogs.
People also search for: dog vomiting and cough · mixed breed dog fungal infection · dog anorexia treatment
Abstract
A 9-year-old female mixed breed dog presented for an acute onset of anorexia, vomiting, and cough. Initial examination and diagnostics revealed a large multilobular cranial mediastinal mass with unidentified fungal organisms on cytology. The disease progressed in spite of therapy until the dog was euthanized 8 months later. Gross necropsy findings were a large multilobular intrathoracic mass, mild pleuritis, and generalized lymphadenopathy. Histologic evaluation showed granulomatous inflammation and necrosis with numerous 20- to 70-micron, periodic acid-Schiff- and Gomori methenamine silver-positive spherules effacing lymph node parenchyma, as well as severe inflammation within the midbrain. Endosporulation was a common finding, and large numbers of fungal hyphae were also present in affected areas. Ribosomal RNA gene sequencing found 100% identity to published sequences of Phanerochaete chrysosporium, the teleomorph form of Sporotrichum pruinosum. This is the first published report of disease caused by natural infection with this basidiomycete organism in animals.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29191132/