Peer-reviewed veterinary case report
How to check if my dog's tumor was fully removed?
By Milovancev, Milan et al.·Published in Veterinary surgery : VS·2017·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Shaved margin histopathology and imprint cytology for assessment of excision in canine mast cell tumors and soft tissue sarcomas.
- Species:
- dog
Plain-English summary
A group of dogs with mast cell tumors and soft tissue sarcomas had their surgical margins checked using different methods after tumor removal. The study found that imprint cytology detected tumor cells in about 21% of cases, while shaved margin histopathology found them in only 3%. However, the agreement between these methods and the standard radial section histopathology was low, meaning they often gave different results. This suggests that while these new methods are possible to use, they may not be as reliable as the traditional approach. More research is needed to see how these methods relate to the chances of the tumor coming back.
People also search for: dog mast cell tumor treatment · soft tissue sarcoma in dogs · how to check for tumor recurrence in dogs
Abstract
OBJECTIVE: To determine the feasibility and agreement of margin assessment by imprint cytology, shaved margin histopathology, and radial section histopathology in canine cutaneous and subcutaneous mast cell tumors (MCT) and soft tissue sarcomas (STS). STUDY DESIGN: Prospective clinical study. SAMPLE POPULATION: Three hundred and forty margins from 72 excised tumors (52 MCT and 20 STS) in 54 client-owned dogs. METHODS: Imprint cytology samples were acquired by pressing glass slides to the cut surgical margin of the freshly excised surgical specimen. Shaved margin samples were obtained from the patient wound bed using a scalpel immediately prior to closure. Radial section histopathology was performed as part of routine histopathologic processing. All margins were assessed as either positive or negative for presence of tumor cells at the surgical margin. Agreement among methods was calculated using Fleiss Kappa coefficients and an association of method, margin direction, and tumor type with positive margin status was evaluated using a general linear mixed model. RESULTS: Positive margin detection rates differed for MCT (imprint cytology 21%, radial section histopathology 9%, and shaved margin histopathology 3%; P < .0001) but not for STS. Intermethod agreement was poor (Fleiss Kappa = 0.051 and 0.176 for MCT and STS, respectively). Margin direction did not influence margin status for either tumor type. CONCLUSION: Imprint cytology and shaved margin histopathology are feasible, but their results are frequently disparate from routine radial section histopathology. Future studies are needed to evaluate the correlation of each method with local recurrence rates.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28460419/