Peer-reviewed veterinary case report
Short-term effects of drilled tissue-engineered meniscus transplant
By Dai, Pengxiu et al.·Published in Frontiers in veterinary science·2023·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Short-term transplantation effect of a tissue-engineered meniscus constructed using drilled allogeneic acellular meniscus and BMSCs.
- Species:
- dog
Plain-English summary
A group of dogs with knee joint injuries received a special type of tissue-engineered meniscus made from donor tissue and stem cells to help repair their damaged cartilage. Researchers found that by drilling holes in the donor meniscus, they could improve the flow of nutrients and support cell growth, leading to better healing. After the surgery, the dogs showed good recovery, with new cartilage forming on the graft and minimal wear on the surrounding joint surfaces. This approach not only helped repair the meniscus but also protected the knee joint and improved its function.
People also search for: dog knee injury treatment · meniscus repair in dogs · stem cell therapy for dog joints
Abstract
During the construction of tissue-engineered meniscus, the low porosity of extracellular matrix restricts the flow of nutrient solution and the migration and proliferation of cells, thus affecting the tissue remodeling after transplantation. In this study, the canine allogeneic meniscus was drilled first and then decellularized. The drilled tissue-engineered menisci (Drilled Allogeneic Acellular Meniscus + Bone Marrow Mesenchymal Stem Cells, BMSCs) were transplanted into the knee joints of model dogs. On the basis of ensuring the mechanical properties, the number of the porosity and the cells implanted in allogeneic acellular meniscus was significantly increased. The expression levels of glycosaminoglycans and type II collagen in the drilled tissue-engineered meniscus were also improved. It was determined that the animals in the experimental group recovered well-compared with those in the control group. The graft surface was covered with new cartilage, the retraction degree was small, and the tissue remodeling was good. The surface wear of the femoral condyle and tibial plateau cartilage was light. The results of this study showed that increasing the porosity of allogeneic meniscus by drilling could not only maintain the mechanical properties of the meniscus and increase the number of implanted cells but also promote cell proliferation and differentiation. After transplantation, the drilled tissue-engineered meniscus provided a good remodeling effectand played a positive role in repairing meniscal injury, protecting articular cartilage and restoring knee joint function.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38046571/