Peer-reviewed veterinary case report
Cabergoline shortens time between heat cycles in female dogs
By Gobello, Cristina et al.·Published in Journal of the American Animal Hospital Association·2004·Small Animal Clinic and Animal Reproduction·View original on PubMed →
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Original publication title: Shortening of interestrous intervals with cabergoline in bitches: a clinical trial.
Plain-English summary
A group of 23 female dogs of various breeds were given a medication called cabergoline to see if it could shorten the time between their heat cycles. The dogs were treated at different stages of their reproductive cycle, and the results showed that those receiving cabergoline had significantly shorter intervals between heats compared to those that did not receive the treatment. On average, the treated dogs experienced their next heat about 184 days after their last one, while untreated dogs had to wait about 239 days. This suggests that cabergoline can effectively help manage the timing of heat cycles in female dogs.
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Abstract
Two consecutive interestrous intervals (n=46) were recorded in 23 bitches of different breeds. At varying times after day 100 from the onset of the second proestrus, cabergoline (5 microg/kg per os q 24 hours) was administered from early (n=11), mid- (n=10), and late (n=2) anestrus until 2 days after the beginning of the following proestrus. Interestrous intervals (IEI) were significantly shorter in the cabergoline-treated time periods when compared to the nontreated IEI (184+/-4.5 days versus 239+/-4.5 days; P<0.01). The mean number of days of cabergoline treatment until the onset of proestrus was 21.4+/-2.9 (least square means and standard error of the mean [LSM+/-SEM]). Mean cabergoline treatment durations beginning in early, mid-, and late anestrus were 27.4+/-3.7, 17.6+/-3.8, and 5+/-3 days (LSM+/-SEM), respectively. A significant correlation was found between the stage of anestrus in which the treatments began and the duration of the treatments required to induce estrus (0.51, P=0.01).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15007046/