Peer-reviewed veterinary case report
Tumor-infiltrating T cells linked to worse cancer in dogs
By Saeki, Kohei et al.·Published in The Journal of veterinary medical science·2012·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Significance of tumor-infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases.
- Species:
- dog
Plain-English summary
A study looked at 140 dogs with mammary gland tumors, which are lumps in the breast area. It found that dogs with malignant (cancerous) tumors had more immune cells called T lymphocytes compared to those with benign (non-cancerous) tumors. The presence of these T lymphocytes was linked to a worse outcome for the dogs with malignant tumors. This information can help veterinarians understand the severity of the tumor and guide treatment options for affected dogs.
People also search for: dog mammary tumor treatment · signs of breast cancer in dogs · canine mammary gland tumor prognosis
Abstract
The numbers of tumor infiltrating T lymphocytes, B lymphocytes and antigen presenting cells were evaluated in an immunohistochemical manner in 140 canine spontaneous mammary gland tumor (MGT) tissues. As a result, we found a statistically significant increase in the number of intratumoral T lymphocytes (23.2 ± 23.8) in the malignant MGT group (n=51) compared with the benign MGT group (14.0 ± 16.0, n=89; P<0.05). Moreover, the high T lymphocyte infiltration in the malignant group correlated with poor prognosis in multivariate analysis (P<0.05). This study indicated the relationship between increased infiltrating T lymphocytes and canine MGT malignancy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21937855/