Peer-reviewed veterinary case report
Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
- Journal:
- Fundamental & clinical pharmacology
- Year:
- 2012
- Authors:
- Fakhfouri, Gohar et al.
- Affiliation:
- Department of Pharmacology
- Species:
- rodent
Abstract
The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP-sensitive potassium channels (KATP) and cGMP, respectively.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21777273/