Peer-reviewed veterinary case report
Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
- Journal:
- Nature neuroscience
- Year:
- 2016
- Authors:
- Ueno, Masaki et al.
- Affiliation:
- Cincinnati Children's Hospital Medical Center · United States
Abstract
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27089020/