Peer-reviewed veterinary case report
Simplified tests to detect low kidney function in cats
By Paepe, Dominique et al.·Published in Journal of feline medicine and surgery·2015·Department of Medicine and Clinical Biology of Small Animals·View original on PubMed →
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Original publication title: Simplified methods for estimating glomerular filtration rate in cats and for detection of cats with low or borderline glomerular filtration rate.
- Species:
- cat
Plain-English summary
A group of 73 cats was studied to find easier ways to check kidney function, specifically looking for early signs of chronic kidney disease (CKD). The researchers found that taking at least three blood samples can help identify cats with low or borderline kidney function without the stress of more complicated tests. While routine blood tests alone weren't reliable for measuring kidney function, they could still effectively spot cats needing further evaluation. These simplified methods could help vets catch kidney issues earlier, allowing for better treatment options.
People also search for: cat kidney disease symptoms · how to test cat kidney function · early signs of chronic kidney disease in cats
Abstract
OBJECTIVES: Diagnosis of early feline chronic kidney disease (CKD) is challenging. Glomerular filtration rate (GFR) is the best overall indicator of kidney function, but multisample plasma clearance methods to determine GFR are labour intensive, time consuming and stressful for feline patients. This study aimed to develop simplified methods to detect decreased GFR in cats. METHODS: Data from a nine-sample combined plasma exogenous creatinine-iohexol clearance test of 73 cats were used. Limited sampling strategies were developed by comparing all sampling time combinations with the complete nine sampling times set and selecting the best sampling time combinations based on maximum relative error. By regression analysis, the ability of routine blood (serum creatinine, serum urea) and urine (urine specific gravity, urinary protein:creatinine ratio) variables to predict GFR or identify cats with low or borderline GFR was examined. Cut-off clearance marker concentrations to predict low or borderline GFR was determined at three time points after marker injection. All procedures were analysed for three clearance markers (exo-iohexol, creatinine, endo-iohexol). RESULTS: For reliable estimation of GFR, at least three blood samples for clinical purposes and five blood samples for research purposes are required. Regression formulae based on routine variables did not reliably predict GFR, but accurately identified cats with low (sensitivity 96.5-98.2%; specificity 60-91.3%) or borderline (sensitivity 91.1-96%; specificity 76.5-81.8%) GFR. Clearance marker concentrations exceeding given marker cut-off concentrations also identified cats with low or borderline GFR with high sensitivities and specificities. CONCLUSIONS AND RELEVANCE: These simplified methods will facilitate the detection of early kidney dysfunction in cats. Early diagnosis allows timely therapeutic intervention, and future studies must reveal whether this improves the long-term outcome of cats with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25518848/