Peer-reviewed veterinary case report
Simulation of nonalcoholic steatohepatitis in rats.
- Journal:
- Bulletin of experimental biology and medicine
- Year:
- 2012
- Authors:
- Karaman, Yu K et al.
- Affiliation:
- Vladivostok Affiliated Department of Far Eastern Center of Respiratory Physiology and Pathology
- Species:
- rodent
Abstract
The new model of nonalcoholic steatohepatitis in rats is based on alimentary effects of hypercaloric diet including much cholesterol and beef fat. This model reproduces structural and functional disorders in the liver, including hepatocyte fatty degeneration, parenchymatous necrosis and fibrosis paralleled by dyslipidemia and is intended for studies of the mechanisms of formation, progress, and therapy of liver diseases of noninfectious origin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22866321/