Simvastatin treatment prolongs the survival of scrapie-infected mice.

Abstract

Statins, drugs that decrease cholesterol biosynthesis, are known to reduce the formation of the disease-associated isoform of the prion protein (PrP) in neuroblastoma cells in vitro. In this study, we report the effects of simvastatin, a clinically approved statin that penetrates the brain, on mice infected with the ME7 strain of scrapie. The decline in motor functions associated with scrapie infection was delayed in mice receiving (1 mg/kg) simvastatin, a dosage used to treat hypercholesterolemia in humans. Simvastatin treatment also significantly prolonged the survival times of infected mice (193 vs. 183 days). These results indicate that low-dosage simvastatin treatment affects the progression of experimental scrapie, and supports the concept that statin treatment may influence the prion pathogenesis.